Complex chimerism

Chimerism after organ transplantation.

Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft. Here, we describe how this hematolymphopoietic chimerism provides an important framework for interpretation of post-transplant phenomena and for initiation of therapeutically oriented transplantation research.

Cardiac chimerism: methods matter.

tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Authors of letters selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed in the original publication. Please submit three typewritten, double-spaced copies of ...

Cyclophosphamide-induced chimerism.

BALB/c mice were injected with cyclophosphamide (Cytoxan) (180-280 mg/kg) i.p., and with 3 X 10T (BALB/c 9 X DBA a ) Fj (CDF) spleen cells i.v. The recipients were bled periodically and their sera tested for DBA y-globulin. All mice had levels of donor y-globulin at 2 weeks; 17/24 still had detectable levels at 6 months. A greater proportion of mice had detectable donor y-globulin for a longer ...

Tolerance , Mixed Chimerism , and

The practical application of chimerism analyses in allogeneic stem cell transplant recipients: blood chimerism is equivalent to marrow chimerism.

BACKGROUND Chimerism defines the amount of donor versus recipient hematopoiesis following allogeneic stem cell transplant (SCT). PCR-based analyses of short tandem repeats (STRs) are commonly used and are accurate and applicable to allogeneic transplant recipients. These analyses are performed on blood and marrow aspirates, but it is unknown if analyses of both are required. We performed a retr...